9gsf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9gsf is ~~ON HOLD until Paper Publication~~

==Mouse PMCA-NPTN complex captured in E1-ATP state without calcium==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9gsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GSF OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9GSF FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=KXP:(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+icosa-5,8,11,14-tetraenoate'>KXP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9gsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gsf OCA], [https://pdbe.org/9gsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gsf RCSB], [https://www.ebi.ac.uk/pdbsum/9gsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gsf ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] Defects in Atp2b2 are associated with early onset profound hearing loss and severe vestibular dysfunction.<ref>PMID:17234811</ref> <ref>PMID:9697703</ref>

== Function ==

[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868).[UniProtKB:Q01814]<ref>PMID:15302868</ref> <ref>PMID:17234811</ref> <ref>PMID:17409239</ref> <ref>PMID:20083513</ref> <ref>PMID:9668038</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Constantin CE]]

[[Category: Fakler B]]

[[Category: Prumbaum D]]

[[Category: Raunser S]]

[[Category: Schulte U]]

[[Category: Sistel O]]

[[Category: Vinayagam D]]

[[Category: Zolles G]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9gsf is ON HOLD  until Paper Publication
+==Mouse PMCA-NPTN complex captured in E1-ATP state without calcium==
+<StructureSection load='9gsf' size='340' side='right'caption='[[9gsf]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9gsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GSF FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=KXP:(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+icosa-5,8,11,14-tetraenoate'>KXP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gsf OCA], [https://pdbe.org/9gsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gsf RCSB], [https://www.ebi.ac.uk/pdbsum/9gsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gsf ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] Defects in Atp2b2 are associated with early onset profound hearing loss and severe vestibular dysfunction.<ref>PMID:17234811</ref> <ref>PMID:9697703</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868).[UniProtKB:Q01814]<ref>PMID:15302868</ref> <ref>PMID:17234811</ref> <ref>PMID:17409239</ref> <ref>PMID:20083513</ref> <ref>PMID:9668038</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Constantin CE]]
+[[Category: Fakler B]]
+[[Category: Prumbaum D]]
+[[Category: Raunser S]]
+[[Category: Schulte U]]
+[[Category: Sistel O]]
+[[Category: Vinayagam D]]
+[[Category: Zolles G]]