9p06: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9p06 is ~~ON HOLD until Paper Publication~~

==Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD12==

~~Authors~~: ~~Goldberg~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[9p06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P06 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9P06 FirstGlance].

~~Description~~: ~~Structure~~ of ~~human Sec23a~~/~~Sec24a~~/~~Sec22b bound~~ to ~~ligand CPD12~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CGA:(2R,3R)-2-[(2-methoxyphenyl)methyl]-3-phenylcyclopropane-1,1-dicarboxylic+acid'>A1CGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: Goldberg, J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9p06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p06 OCA], [https://pdbe.org/9p06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p06 RCSB], [https://www.ebi.ac.uk/pdbsum/9p06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p06 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>

== Function ==

[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Goldberg J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9p06 is ON HOLD  until Paper Publication
+==Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD12==
+<StructureSection load='9p06' size='340' side='right'caption='[[9p06]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Goldberg, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9p06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P06 FirstGlance]. <br>
-Description: Structure of human Sec23a/Sec24a/Sec22b bound to ligand CPD12
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CGA:(2R,3R)-2-[(2-methoxyphenyl)methyl]-3-phenylcyclopropane-1,1-dicarboxylic+acid'>A1CGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Goldberg, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p06 OCA], [https://pdbe.org/9p06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p06 RCSB], [https://www.ebi.ac.uk/pdbsum/9p06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p06 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Goldberg J]]