9vvj: Difference between revisions
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The entry | ==Cryo-EM structure of the erlin1/2 complex purified using DDM and GDN== | ||
<StructureSection load='9vvj' size='340' side='right'caption='[[9vvj]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9vvj]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VVJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vvj OCA], [https://pdbe.org/9vvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vvj RCSB], [https://www.ebi.ac.uk/pdbsum/9vvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vvj ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Autosomal recessive spastic paraplegia type 62. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ERLN1_HUMAN ERLN1_HUMAN] Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (PubMed:37683630). Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).<ref>PMID:19240031</ref> <ref>PMID:24217618</ref> <ref>PMID:37683630</ref> (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.<ref>PMID:31810281</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao N]] | |||
[[Category: Yan L]] | |||
Latest revision as of 08:06, 25 March 2026
Cryo-EM structure of the erlin1/2 complex purified using DDM and GDN
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