9pqd: Difference between revisions

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'''Unreleased structure'''


The entry 9pqd is ON HOLD
==Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149==
 
<StructureSection load='9pqd' size='340' side='right'caption='[[9pqd]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
Authors: Srinivasan, K., Wu, Y., Billesboelle, C., Kim, J.Y., Manglik, A., Shoichet, B.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9pqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PQD FirstGlance]. <br>
Description: Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CIZ:1-methyl-6-(1,2,3,6-tetrahydropyridin-5-yl)indole'>A1CIZ</scene></td></tr>
[[Category: Kim, J.Y]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pqd OCA], [https://pdbe.org/9pqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pqd RCSB], [https://www.ebi.ac.uk/pdbsum/9pqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pqd ProSAT]</span></td></tr>
[[Category: Billesboelle, C]]
</table>
[[Category: Shoichet, B.K]]
== Function ==
[[Category: Srinivasan, K]]
[https://www.uniprot.org/uniprot/ADA2A_HUMAN ADA2A_HUMAN] Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.<ref>PMID:23105096</ref>
[[Category: Wu, Y]]
== References ==
[[Category: Manglik, A]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Billesboelle C]]
[[Category: Kim JY]]
[[Category: Manglik A]]
[[Category: Shoichet BK]]
[[Category: Srinivasan K]]
[[Category: Wu Y]]
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