9w0p: Difference between revisions
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==CryoEM structure of T2R14 in complex with chlorhexidine and heterotrimeric G protein complex== | |||
<StructureSection load='9w0p' size='340' side='right'caption='[[9w0p]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9w0p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W0P FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XC9:N,N-hexane-1,6-diylbis[N-(4-chlorophenyl)triimidodicarbonic+diamide]'>XC9</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w0p OCA], [https://pdbe.org/9w0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w0p RCSB], [https://www.ebi.ac.uk/pdbsum/9w0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w0p ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han X]] | |||
[[Category: Tan Q]] | |||
[[Category: Wu B]] | |||
[[Category: Yu Y]] | |||
[[Category: Zhao Q]] | |||
Latest revision as of 06:42, 22 April 2026
CryoEM structure of T2R14 in complex with chlorhexidine and heterotrimeric G protein complex
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