9s9f: Difference between revisions
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New page: '''Unreleased structure''' The entry 9s9f is ON HOLD Authors: Burlet, N.J., Bertelsen, A.B., Laustsen, A.H., Morth, J.P. Description: Crystal of cardiotoxin (P01468) Naja pallida [[Cat... |
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==Crystal of cardiotoxin (P01468) Naja pallida== | |||
<StructureSection load='9s9f' size='340' side='right'caption='[[9s9f]], [[Resolution|resolution]] 1.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9s9f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_pallida Naja pallida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S9F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s9f OCA], [https://pdbe.org/9s9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s9f RCSB], [https://www.ebi.ac.uk/pdbsum/9s9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s9f ProSAT]</span></td></tr> | ||
[[Category: Bertelsen | </table> | ||
[[Category: | == Function == | ||
[[Category: Laustsen | [https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Naja pallida]] | |||
[[Category: Bertelsen AB]] | |||
[[Category: Burlet NJ]] | |||
[[Category: Laustsen AH]] | |||
[[Category: Morth JP]] | |||
Latest revision as of 05:02, 19 August 2026
Crystal of cardiotoxin (P01468) Naja pallida
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