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New page: left|200px<br /> <applet load="1zoq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zoq, resolution 2.37Å" /> '''IRF3-CBP complex'''...
 
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[[Image:1zoq.gif|left|200px]]<br />
<applet load="1zoq" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1zoq, resolution 2.37&Aring;" />
'''IRF3-CBP complex'''<br />


==Overview==
==IRF3-CBP complex==
Interferon regulatory factor (IRF) 3 plays a critical role in triggering, the activation of interferon antiviral genes. The structure of IRF-3 in, association with the CBP/p300 coactivator by in this issue of Structure, illuminates the mechanism of IRF activation and the structural, flexibilities inherent in CBP/p300.
<StructureSection load='1zoq' size='340' side='right'caption='[[1zoq]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1zoq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zoq OCA], [https://pdbe.org/1zoq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zoq RCSB], [https://www.ebi.ac.uk/pdbsum/1zoq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zoq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRF3_HUMAN IRF3_HUMAN] Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zoq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zoq ConSurf].
<div style="clear:both"></div>


==Disease==
==See Also==
Known diseases associated with this structure: Blue-cone monochromacy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303900 303900]], Colorblindness, protan OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303900 303900]], Rubenstein-Taybi syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600140 600140]]
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
 
*[[Interferon regulatory factor|Interferon regulatory factor]]
==About this Structure==
__TOC__
1ZOQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA].
</StructureSection>
 
==Reference==
IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16154077 16154077]
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Lin, K.]]
[[Category: Lin K]]
[[Category: Qin, B.]]
[[Category: Qin B]]
[[Category: transcription regulation]]
[[Category: transferase]]
 
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Retrieved from "https://proteopedia.org/1zoq"