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'''Unreleased structure'''


The entry 9mc9 is ON HOLD  until Paper Publication
==Cryo-EM structure of Human UBA1-UBE2O-Ub -Transthiolation state 1==
 
<StructureSection load='9mc9' size='340' side='right'caption='[[9mc9]], [[Resolution|resolution]] 3.37&Aring;' scene=''>
Authors: Chen, P.-T., Wu, K.-P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9mc9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MC9 FirstGlance]. <br>
Description: Cryo-EM structure of Human UBA1-UBE2O-Ub -Transthiolation state 1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.37&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
[[Category: Chen, P.-T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mc9 OCA], [https://pdbe.org/9mc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mc9 RCSB], [https://www.ebi.ac.uk/pdbsum/9mc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mc9 ProSAT]</span></td></tr>
[[Category: Wu, K.-P]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/UBA1_HUMAN UBA1_HUMAN] X-linked distal arthrogryposis multiplex congenita. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/UBA1_HUMAN UBA1_HUMAN] Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.<ref>PMID:22456334</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen P-T]]
[[Category: Wu K-P]]
Retrieved from "https://proteopedia.org/9mc9"