9q5e: Difference between revisions
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New page: '''Unreleased structure''' The entry 9q5e is ON HOLD Authors: Iverson, T.M. Description: Hsa bound to Neu5Ac alpha2,3 Gal beta OMe Category: Unreleased Structures [[Category: Ivers... |
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==Hsa bound to Neu5Ac alpha2,3 Gal beta OMe== | |||
<StructureSection load='9q5e' size='340' side='right'caption='[[9q5e]], [[Resolution|resolution]] 1.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9q5e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus Streptococcus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q5E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MBG:METHYL-BETA-GALACTOSE'>MBG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
[[Category: Iverson | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q5e OCA], [https://pdbe.org/9q5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q5e RCSB], [https://www.ebi.ac.uk/pdbsum/9q5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q5e ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HSA_STRGC HSA_STRGC] A cell wall protein involved with PadA in host cell interactions required for colonization and pathogensis (Probable) (PubMed:19884334, PubMed:27616700). Mediates hemagglutination and adherence to ghst glycoproteins (PubMed:11854202). Recognizes fetuin-A (AHSG), a highly glycosylated human plasma protein, also involved in recognition of human platelets, probably via platelet glycoprotein Ib alpha (GP1BA) (PubMed:19884334). Acts in concert with PadA to promote binding to glycosylated human fibronectin (FN1) and vitronectin (VTN), and biofilm formation. Plays a major role in fibronectin and vitronectin binding; binding is mediated by glycosylated regions. Probably mediates interaction of PadA with resting platelets (PubMed:27616700).<ref>PMID:11854202</ref> <ref>PMID:19884334</ref> <ref>PMID:27616700</ref> <ref>PMID:11854202</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptococcus]] | |||
[[Category: Iverson TM]] | |||
Latest revision as of 06:32, 26 November 2025
Hsa bound to Neu5Ac alpha2,3 Gal beta OMe
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