1wh0: Difference between revisions

Latest revision as of 09:28, 6 December 2023

Solution structure of the CS domain of human USP19

Structural highlights

1wh0 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

UBP19_HUMAN Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.^[1] ^[2] ^[3] ^[4]

References

↑ Hassink GC, Zhao B, Sompallae R, Altun M, Gastaldello S, Zinin NV, Masucci MG, Lindsten K. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep. 2009 Jul;10(7):755-61. Epub 2009 May 22. PMID:19465887 doi:https://dx.doi.org/embor200969
↑ Mei Y, Hahn AA, Hu S, Yang X. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. J Biol Chem. 2011 Oct 14;286(41):35380-7. doi: 10.1074/jbc.M111.282020. Epub 2011, Aug 17. PMID:21849505 doi:https://dx.doi.org/10.1074/jbc.M111.282020
↑ Altun M, Zhao B, Velasco K, Liu H, Hassink G, Paschke J, Pereira T, Lindsten K. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia. J Biol Chem. 2012 Jan 13;287(3):1962-9. doi: 10.1074/jbc.M111.305615. Epub 2011, Nov 29. PMID:22128162 doi:https://dx.doi.org/10.1074/jbc.M111.305615
↑ Iphofer A, Kummer A, Nimtz M, Ritter A, Arnold T, Frank R, van den Heuvel J, Kessler BM, Jansch L, Franke R. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. Chembiochem. 2012 Jul 9;13(10):1416-20. doi: 10.1002/cbic.201200261. Epub 2012, Jun 11. PMID:22689415 doi:10.1002/cbic.201200261

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Hassink GC, Zhao B, Sompallae R, Altun M, Gastaldello S, Zinin NV, Masucci MG, Lindsten K. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep. 2009 Jul;10(7):755-61. Epub 2009 May 22. PMID:19465887 doi:https://dx.doi.org/embor200969

[2] Mei Y, Hahn AA, Hu S, Yang X. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. J Biol Chem. 2011 Oct 14;286(41):35380-7. doi: 10.1074/jbc.M111.282020. Epub 2011, Aug 17. PMID:21849505 doi:https://dx.doi.org/10.1074/jbc.M111.282020

[3] Altun M, Zhao B, Velasco K, Liu H, Hassink G, Paschke J, Pereira T, Lindsten K. Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia. J Biol Chem. 2012 Jan 13;287(3):1962-9. doi: 10.1074/jbc.M111.305615. Epub 2011, Nov 29. PMID:22128162 doi:https://dx.doi.org/10.1074/jbc.M111.305615

[4] Iphofer A, Kummer A, Nimtz M, Ritter A, Arnold T, Frank R, van den Heuvel J, Kessler BM, Jansch L, Franke R. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. Chembiochem. 2012 Jul 9;13(10):1416-20. doi: 10.1002/cbic.201200261. Epub 2012, Jun 11. PMID:22689415 doi:10.1002/cbic.201200261

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-[[Image:1wh0.jpg|left|200px]]
-<!--
+==Solution structure of the CS domain of human USP19==
-The line below this paragraph, containing "STRUCTURE_1wh0", creates the "Structure Box" on the page.
+<StructureSection load='1wh0' size='340' side='right'caption='[[1wh0]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1wh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WH0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wh0 OCA], [https://pdbe.org/1wh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wh0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wh0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wh0 TOPSAN]</span></td></tr>
-{{STRUCTURE_1wh0|  PDB=1wh0  |  SCENE=  }}
+</table>
+== Function ==
-'''Solution structure of the CS domain of human USP19'''
+[https://www.uniprot.org/uniprot/UBP19_HUMAN UBP19_HUMAN] Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.<ref>PMID:19465887</ref> <ref>PMID:21849505</ref> <ref>PMID:22128162</ref> <ref>PMID:22689415</ref>
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-WH0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WH0 OCA].
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Ubiquitin thiolesterase]]
+[[Category: Inoue M]]
-[[Category: Inoue, M.]]
+[[Category: Kigawa T]]
-[[Category: Kigawa, T.]]
+[[Category: Koshiba S]]
-[[Category: Koshiba, S.]]
+[[Category: Nakanishi T]]
-[[Category: Nakanishi, T.]]
+[[Category: Tochio N]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Tochio, N.]]
-[[Category: Yokoyama, S.]]
-[[Category: Cs domain]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Usp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:39:15 2008''

1wh0: Difference between revisions

Latest revision as of 09:28, 6 December 2023

Solution structure of the CS domain of human USP19

Structural highlights

Function

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