9sfs: Difference between revisions
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New page: '''Unreleased structure''' The entry 9sfs is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Human PPAR alpha ligand binding domain in complex with 10-HSA ligand== | |||
<StructureSection load='9sfs' size='340' side='right'caption='[[9sfs]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9sfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SFS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1J4E:(10~{S})-10-oxidanyloctadecanoic+acid'>A1J4E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sfs OCA], [https://pdbe.org/9sfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sfs RCSB], [https://www.ebi.ac.uk/pdbsum/9sfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sfs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bui S]] | |||
[[Category: Dandekar S]] | |||
[[Category: Kramer DJ]] | |||
Latest revision as of 06:28, 8 April 2026
Human PPAR alpha ligand binding domain in complex with 10-HSA ligand
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