9s2n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9s2n is ~~ON HOLD~~ ~~until Paper Publication~~

==Ternary structure of 14-3-3s, CRAF V263A NS mutant phosphopeptide (pS259), and compound 23 (1083848)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9s2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S2N OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9S2N FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=WQI:2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide'>WQI</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9s2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s2n OCA], [https://pdbe.org/9s2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s2n RCSB], [https://www.ebi.ac.uk/pdbsum/9s2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s2n ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arkin MR]]

[[Category: Brunsveld L]]

[[Category: Crawford MC]]

[[Category: Konstantinidou M]]

[[Category: Ottmann C]]

[[Category: Pennings MAM]]

[[Category: Vickery HR]]

[[Category: Virta JM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9s2n is ON HOLD  until Paper Publication
+==Ternary structure of 14-3-3s, CRAF V263A NS mutant phosphopeptide (pS259), and compound 23 (1083848)==
+<StructureSection load='9s2n' size='340' side='right'caption='[[9s2n]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9s2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S2N FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=WQI:2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide'>WQI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s2n OCA], [https://pdbe.org/9s2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s2n RCSB], [https://www.ebi.ac.uk/pdbsum/9s2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s2n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arkin MR]]
+[[Category: Brunsveld L]]
+[[Category: Crawford MC]]
+[[Category: Konstantinidou M]]
+[[Category: Ottmann C]]
+[[Category: Pennings MAM]]
+[[Category: Vickery HR]]
+[[Category: Virta JM]]