9w0r: Difference between revisions
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==Cryo-EM structure of apo-T2R46 in complex with heterotrimeric G protein== | |||
<StructureSection load='9w0r' size='340' side='right'caption='[[9w0r]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9w0r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W0R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w0r OCA], [https://pdbe.org/9w0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w0r RCSB], [https://www.ebi.ac.uk/pdbsum/9w0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w0r ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/T2R46_HUMAN T2R46_HUMAN] Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han X]] | |||
[[Category: Tan Q]] | |||
[[Category: Wu B]] | |||
[[Category: Yu Y]] | |||
[[Category: Zhao Q]] | |||
Latest revision as of 06:43, 22 April 2026
Cryo-EM structure of apo-T2R46 in complex with heterotrimeric G protein
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