9w0w: Difference between revisions
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==CryoEM structure of the T2R46 in complex with strychine and heterotrimeric G protein complex== | |||
<StructureSection load='9w0w' size='340' side='right'caption='[[9w0w]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9w0w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W0W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w0w OCA], [https://pdbe.org/9w0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w0w RCSB], [https://www.ebi.ac.uk/pdbsum/9w0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w0w ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/T2R46_HUMAN T2R46_HUMAN] Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han X]] | |||
[[Category: Tan Q]] | |||
[[Category: Wu B]] | |||
[[Category: Yu Y]] | |||
[[Category: Zhao Q]] | |||
Latest revision as of 06:43, 22 April 2026
CryoEM structure of the T2R46 in complex with strychine and heterotrimeric G protein complex
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