1zrh: Difference between revisions
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New page: left|200px<br /> <applet load="1zrh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zrh, resolution 2.10Å" /> '''Crystal structure o... |
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== | ==Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP== | ||
<StructureSection load='1zrh' size='340' side='right'caption='[[1zrh]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1zrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZRH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [https://pdbe.org/1zrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB], [https://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zrh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HS3S1_HUMAN HS3S1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.<ref>PMID:9346953</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zrh_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zrh ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | |||
[[Category: Arrowsmith | [[Category: Bochkarev A]] | ||
[[Category: Bochkarev | [[Category: Dombrovski L]] | ||
[[Category: Dombrovski | [[Category: Dong A]] | ||
[[Category: Dong | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Loppnau P]] | ||
[[Category: Loppnau | [[Category: Plotnikov AN]] | ||
[[Category: Plotnikov | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | |||
Latest revision as of 07:46, 30 October 2024
Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
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