9sms: Difference between revisions

Latest revision as of 07:19, 17 June 2026

BRCA1-A complex: Ubiquitin bound to BRE at the wrist site (focused 3D class)

Structural highlights

9sms is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

ABRX1_HUMAN Disease susceptibility is associated with variants affecting the gene represented in this entry.

Function

ABRX1_HUMAN Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25;316(5828):1194-8. PMID:17525340 doi:10.1126/science.1139476
↑ Liu Z, Wu J, Yu X. CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol. 2007 Aug;14(8):716-20. Epub 2007 Jul 22. PMID:17643121 doi:https://dx.doi.org/nsmb1279
↑ Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007 Aug;14(8):710-5. Epub 2007 Jul 22. PMID:17643122 doi:https://dx.doi.org/nsmb1277
↑ Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5. PMID:18077395 doi:https://dx.doi.org/0710061104
↑ Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009 Mar 15;23(6):719-28. doi: 10.1101/gad.1770609. Epub 2009 Mar 4. PMID:19261748 doi:10.1101/gad.1770609
↑ Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R. Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions. Sci Transl Med. 2012 Feb 22;4(122):122ra23. PMID:22357538 doi:10.1126/scitranslmed.3003223
↑ Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol Cell. 2016 Jan 13. pii: S1097-2765(15)00973-9. doi:, 10.1016/j.molcel.2015.12.017. PMID:26778126 doi:https://dx.doi.org/10.1016/j.molcel.2015.12.017

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25;316(5828):1194-8. PMID:17525340 doi:10.1126/science.1139476

[2] Liu Z, Wu J, Yu X. CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol. 2007 Aug;14(8):716-20. Epub 2007 Jul 22. PMID:17643121 doi:https://dx.doi.org/nsmb1279

[3] Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007 Aug;14(8):710-5. Epub 2007 Jul 22. PMID:17643122 doi:https://dx.doi.org/nsmb1277

[4] Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5. PMID:18077395 doi:https://dx.doi.org/0710061104

[5] Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009 Mar 15;23(6):719-28. doi: 10.1101/gad.1770609. Epub 2009 Mar 4. PMID:19261748 doi:10.1101/gad.1770609

[6] Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R. Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions. Sci Transl Med. 2012 Feb 22;4(122):122ra23. PMID:22357538 doi:10.1126/scitranslmed.3003223

[7] Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol Cell. 2016 Jan 13. pii: S1097-2765(15)00973-9. doi:, 10.1016/j.molcel.2015.12.017. PMID:26778126 doi:https://dx.doi.org/10.1016/j.molcel.2015.12.017

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9sms is ON HOLD
+==BRCA1-A complex: Ubiquitin bound to BRE at the wrist site (focused 3D class)==
+<StructureSection load='9sms' size='340' side='right'caption='[[9sms]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-Authors: Murachelli, A.G., Sixma, T.K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9sms]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SMS FirstGlance]. <br>
-Description: BRCA1-A complex: Ubiquitin bound to BRE at the wrist site (focused 3D class)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sms OCA], [https://pdbe.org/9sms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sms RCSB], [https://www.ebi.ac.uk/pdbsum/9sms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sms ProSAT]</span></td></tr>
-[[Category: Sixma, T.K]]
+</table>
-[[Category: Murachelli, A.G]]
+== Disease ==
+[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/ABRX1_HUMAN ABRX1_HUMAN] Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.<ref>PMID:17525340</ref> <ref>PMID:17643121</ref> <ref>PMID:17643122</ref> <ref>PMID:18077395</ref> <ref>PMID:19261748</ref> <ref>PMID:22357538</ref> <ref>PMID:26778126</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Murachelli AG]]
+[[Category: Sixma TK]]

9sms: Difference between revisions

Latest revision as of 07:19, 17 June 2026

BRCA1-A complex: Ubiquitin bound to BRE at the wrist site (focused 3D class)

Structural highlights

Disease

Function

References

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