9sn8: Difference between revisions
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New page: '''Unreleased structure''' The entry 9sn8 is ON HOLD Authors: Didierjean, C., Favier, F., Mathiot, S. Description: Crystal structure of anthocyanin-related glutathione transferase from... |
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The | ==Crystal structure of anthocyanin-related glutathione transferase from bilberry== | ||
<StructureSection load='9sn8' size='340' side='right'caption='[[9sn8]], [[Resolution|resolution]] 2.34Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9sn8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinium_myrtillus Vaccinium myrtillus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SN8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sn8 OCA], [https://pdbe.org/9sn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sn8 RCSB], [https://www.ebi.ac.uk/pdbsum/9sn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sn8 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The anthocyanin biosynthetic pathway (ABP), a branch of the phenylpropanoid pathway, is responsible for the production of a wide range of flavonoid compounds in plants. Anthocyanin-related glutathione transferases (arGSTs) have long been proposed to act as non-catalytic carrier proteins, mediating the vacuolar sequestration of anthocyanins. However, recent structural and biochemical evidence has suggested a potential catalytic role for arGSTs in the ABP, notably in catalyzing the dehydration of flavan-3,3,4-triol to anthocyanidin. Despite their importance, only a limited number of arGSTs have been characterized biochemically and structurally. Here, we investigated the arGST isoform from bilberry, one of the richest fruit sources of anthocyanins. We showed that the expression of the arGST gene in bilberry increases during fruit ripening in parallel with other ABP genes and putative transcription factors. Biochemical and structural analyses highlighted the remarkable ability of GSTs to adapt to their substrates and revealed a possible inhibitory effect of quercetin on arGST activity, as quercetin is a by-product of the anthocyanin biosynthetic pathway. | |||
Structural and biochemical insights into an anthocyanin-related glutathione transferase from bilberry and its inhibition by quercetin.,Morette L, Mathiot S, Rochoux S, Schwander T, Schwartz M, Nguyen HM, Favier F, Buller R, Hecker A, Didierjean C Int J Biol Macromol. 2026 Jul 7;376:153396. doi: 10.1016/j.ijbiomac.2026.153396. PMID:42413677<ref>PMID:42413677</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Didierjean | <div class="pdbe-citations 9sn8" style="background-color:#fffaf0;"></div> | ||
[[Category: Favier | == References == | ||
[[Category: Mathiot | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vaccinium myrtillus]] | |||
[[Category: Didierjean C]] | |||
[[Category: Favier F]] | |||
[[Category: Mathiot S]] | |||
