1zsy: Difference between revisions

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New page: left|200px<br /> <applet load="1zsy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zsy, resolution 1.75Å" /> '''The structure of hu...
 
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[[Image:1zsy.gif|left|200px]]<br />
<applet load="1zsy" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1zsy, resolution 1.75&Aring;" />
'''The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)'''<br />


==About this Structure==
==The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)==
1ZSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trans-2-enoyl-CoA_reductase_(NADPH) Trans-2-enoyl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.38 1.3.1.38] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA].  
<StructureSection load='1zsy' size='340' side='right'caption='[[1zsy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1zsy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsy OCA], [https://pdbe.org/1zsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zsy RCSB], [https://www.ebi.ac.uk/pdbsum/1zsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zsy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MECR_HUMAN MECR_HUMAN] Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zsy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zsy ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Trans-2-enoyl-CoA reductase (NADPH)]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Edwards A]]
[[Category: Delft, F.von.]]
[[Category: Johansson C]]
[[Category: Edwards, A.]]
[[Category: Kavanagh KL]]
[[Category: Johansson, C.]]
[[Category: Lukacik P]]
[[Category: Kavanagh, K.L.]]
[[Category: Oppermann U]]
[[Category: Lukacik, P.]]
[[Category: Shafqat N]]
[[Category: Oppermann, U.]]
[[Category: Smee C]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Sundstrom M]]
[[Category: Shafqat, N.]]
[[Category: Von Delft F]]
[[Category: Smee, C.]]
[[Category: Sundstrom, M.]]
[[Category: GOL]]
[[Category: SO4]]
[[Category: 2-enoyl thioester reductase]]
[[Category: fatty acid synthesis (type 2)]]
[[Category: medium-chain dehydrogenase/reductase]]
[[Category: oxidoreductase]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
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Retrieved from "https://proteopedia.org/1zsy"