9y5q: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
m Protected "9y5q" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 9y5q is ON HOLD
==Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap==
 
<StructureSection load='9y5q' size='340' side='right'caption='[[9y5q]], [[Resolution|resolution]] 4.73&Aring;' scene=''>
Authors: Nam, Y.W., Zhang, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9y5q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y5Q FirstGlance]. <br>
Description: Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.73&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B92:N-(4,4-difluorocyclohexyl)-2-(3-methyl-1H-pyrazol-1-yl)-6-(morpholin-4-yl)pyrimidin-4-amine'>A1B92</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
[[Category: Zhang, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y5q OCA], [https://pdbe.org/9y5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y5q RCSB], [https://www.ebi.ac.uk/pdbsum/9y5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y5q ProSAT]</span></td></tr>
[[Category: Nam, Y.W]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).<ref>PMID:17157250</ref> <ref>PMID:18796614</ref> <ref>PMID:26148990</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Nam YW]]
[[Category: Zhang M]]
Retrieved from "https://proteopedia.org/9y5q"