9y6e: Difference between revisions

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New page: '''Unreleased structure''' The entry 9y6e is ON HOLD until Paper Publication Authors: Szabla, R., Rok, M., Junop, M.S. Description: Crystal structure of PprA from Deinococcus radiodura...
 
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'''Unreleased structure'''


The entry 9y6e is ON HOLD  until Paper Publication
==Crystal structure of PprA from Deinococcus radiodurans in complex with DNA duplex==
 
<StructureSection load='9y6e' size='340' side='right'caption='[[9y6e]], [[Resolution|resolution]] 5.79&Aring;' scene=''>
Authors: Szabla, R., Rok, M., Junop, M.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9y6e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y6E FirstGlance]. <br>
Description: Crystal structure of PprA from Deinococcus radiodurans in complex with DNA duplex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.79&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y6e OCA], [https://pdbe.org/9y6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y6e RCSB], [https://www.ebi.ac.uk/pdbsum/9y6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y6e ProSAT]</span></td></tr>
[[Category: Rok, M]]
</table>
[[Category: Junop, M.S]]
== Function ==
[[Category: Szabla, R]]
[https://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Junop MS]]
[[Category: Rok M]]
[[Category: Szabla R]]
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