9q7n: Difference between revisions

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'''Unreleased structure'''


The entry 9q7n is ON HOLD  until Paper Publication
==Cofilin barbed end, cofilin on the two barbed end subunits==
 
<StructureSection load='9q7n' size='340' side='right'caption='[[9q7n]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9q7n]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q7N FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q7n OCA], [https://pdbe.org/9q7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q7n RCSB], [https://www.ebi.ac.uk/pdbsum/9q7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q7n ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/COF2_HUMAN COF2_HUMAN] Typical nemaline myopathy. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/COF2_HUMAN COF2_HUMAN] Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).[UniProtKB:P45591]<ref>PMID:19752190</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Dominguez R]]
[[Category: Palmer NJ]]
Retrieved from "https://proteopedia.org/9q7n"