9wvh: Difference between revisions

Latest revision as of 07:38, 8 October 2025

Crystal structure of TONSL UBL domain

Structural highlights

9wvh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.96Å
Ligands:	NA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TONSL_HUMAN Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.^[1] ^[2] ^[3] ^[4]

References

↑ O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 , Nov 4. PMID:21055983 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.024
↑ Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 , Nov 4. PMID:21055984 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.023
↑ O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 , Nov 4. PMID:21055985 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.022
↑ Ray P, Zhang DH, Elias JA, Ray A. Cloning of a differentially expressed I kappa B-related protein. J Biol Chem. 1995 May 5;270(18):10680-5. PMID:7738005

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 , Nov 4. PMID:21055983 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.024

[2] Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 , Nov 4. PMID:21055984 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.023

[3] O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 , Nov 4. PMID:21055985 doi:https://dx.doi.org/10.1016/j.molcel.2010.10.022

[4] Ray P, Zhang DH, Elias JA, Ray A. Cloning of a differentially expressed I kappa B-related protein. J Biol Chem. 1995 May 5;270(18):10680-5. PMID:7738005

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9wvh is ON HOLD
+==Crystal structure of TONSL UBL domain==
+<StructureSection load='9wvh' size='340' side='right'caption='[[9wvh]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
-Authors: Karmakar, A., Roy, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9wvh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WVH FirstGlance]. <br>
-Description: Crystal structure of TONSL UBL domain
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Roy, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wvh OCA], [https://pdbe.org/9wvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wvh RCSB], [https://www.ebi.ac.uk/pdbsum/9wvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wvh ProSAT]</span></td></tr>
-[[Category: Karmakar, A]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TONSL_HUMAN TONSL_HUMAN] Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.<ref>PMID:21055983</ref> <ref>PMID:21055984</ref> <ref>PMID:21055985</ref> <ref>PMID:7738005</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Karmakar A]]
+[[Category: Roy S]]

9wvh: Difference between revisions

Latest revision as of 07:38, 8 October 2025

Crystal structure of TONSL UBL domain

Structural highlights

Function

References

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