9wn3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9wn3 is ~~ON HOLD until 2027~~-09-04

==Crystal structure of W27-Fab in complex with an epitope peptide from serine hydroxymethyltransferase (SHMT)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9wn3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WN3 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9WN3 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wn3 OCA], [https://pdbe.org/9wn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wn3 RCSB], [https://www.ebi.ac.uk/pdbsum/9wn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wn3 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GLYA_ECOLI GLYA_ECOLI] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of allothreonine and 3-phenylserine. Also catalyzes the irreversible conversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.<ref>PMID:6190704</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Escherichia coli]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Chek MF]]

[[Category: Hakoshima T]]

[[Category: Mori T]]

[[Category: Shinkura R]]

[[Category: Yoshihara T]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9wn3 is ON HOLD  until 2027-09-04
+==Crystal structure of W27-Fab in complex with an epitope peptide from serine hydroxymethyltransferase (SHMT)==
+<StructureSection load='9wn3' size='340' side='right'caption='[[9wn3]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9wn3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WN3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wn3 OCA], [https://pdbe.org/9wn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wn3 RCSB], [https://www.ebi.ac.uk/pdbsum/9wn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wn3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLYA_ECOLI GLYA_ECOLI] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of allothreonine and 3-phenylserine. Also catalyzes the irreversible conversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.<ref>PMID:6190704</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Chek MF]]
+[[Category: Hakoshima T]]
+[[Category: Mori T]]
+[[Category: Shinkura R]]
+[[Category: Yoshihara T]]