9t0e: Difference between revisions
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==Structure of Crimean Congo hemorrhagic fever virus (CCHFV) L protein bound to 5' vRNA and nanobody 20096.== | |||
<StructureSection load='9t0e' size='340' side='right'caption='[[9t0e]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9t0e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_virus_strain_IbAr10200 Crimean-Congo hemorrhagic fever virus strain IbAr10200] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T0E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t0e OCA], [https://pdbe.org/9t0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t0e RCSB], [https://www.ebi.ac.uk/pdbsum/9t0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t0e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Crimean-Congo hemorrhagic fever virus strain IbAr10200]] | |||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | |||
[[Category: Carrique L]] | |||
[[Category: Grimes JM]] | |||
[[Category: Keown JR]] | |||
Latest revision as of 07:20, 17 June 2026
Structure of Crimean Congo hemorrhagic fever virus (CCHFV) L protein bound to 5' vRNA and nanobody 20096.
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