9x7t: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9x7t is ~~ON HOLD~~

==Dengue 3 NS5 methyltransferase bound to S-Adenosyl-L-homocysteine and Herbacetin==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9x7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X7T OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9X7T FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L1Z:2-(4-hydroxyphenyl)-3,5,7,8-tetrakis(oxidanyl)chromen-4-one'>A1L1Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x7t OCA], [https://pdbe.org/9x7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x7t RCSB], [https://www.ebi.ac.uk/pdbsum/9x7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x7t ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/C1KBQ3_DENV3 C1KBQ3_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521] Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601]

__TOC__

</StructureSection>

[[Category: Dengue virus 3]]

[[Category: Large Structures]]

[[Category: Bhutkar M]]

[[Category: Kumar P]]

[[Category: Tomar S]]

[[Category: Verma S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9x7t is ON HOLD
+==Dengue 3 NS5 methyltransferase bound to S-Adenosyl-L-homocysteine and Herbacetin==
+<StructureSection load='9x7t' size='340' side='right'caption='[[9x7t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9x7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9X7T FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L1Z:2-(4-hydroxyphenyl)-3,5,7,8-tetrakis(oxidanyl)chromen-4-one'>A1L1Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x7t OCA], [https://pdbe.org/9x7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x7t RCSB], [https://www.ebi.ac.uk/pdbsum/9x7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x7t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/C1KBQ3_DENV3 C1KBQ3_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317]  Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521]  Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601]
+__TOC__
+</StructureSection>
+[[Category: Dengue virus 3]]
+[[Category: Large Structures]]
+[[Category: Bhutkar M]]
+[[Category: Kumar P]]
+[[Category: Tomar S]]
+[[Category: Verma S]]