9x9j: Difference between revisions
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==Structure of HCoV-229E spike proteins on virions by subtomogram averaging: RBD-closed and S2-compact== | |||
<StructureSection load='9x9j' size='340' side='right'caption='[[9x9j]], [[Resolution|resolution]] 4.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9x9j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9X9J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.55Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9x9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x9j OCA], [https://pdbe.org/9x9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x9j RCSB], [https://www.ebi.ac.uk/pdbsum/9x9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x9j ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q1HVM6_CVH22 Q1HVM6_CVH22] S1 region attaches the virion to the cell membrane by interacting with the host receptor, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human coronavirus 229E]] | |||
[[Category: Large Structures]] | |||
[[Category: Li S]] | |||
[[Category: Liang J]] | |||
[[Category: Peng C]] | |||
Latest revision as of 16:32, 25 September 2026
Structure of HCoV-229E spike proteins on virions by subtomogram averaging: RBD-closed and S2-compact
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