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[[Image:1wxv.gif|left|200px]]


<!--
==Solution structure of the ubiquitin domain of BCL-2 binding athanogene-1==
The line below this paragraph, containing "STRUCTURE_1wxv", creates the "Structure Box" on the page.
<StructureSection load='1wxv' size='340' side='right'caption='[[1wxv]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxv OCA], [https://pdbe.org/1wxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxv RCSB], [https://www.ebi.ac.uk/pdbsum/1wxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxv ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxv TOPSAN]</span></td></tr>
{{STRUCTURE_1wxv| PDB=1wxv |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxv ConSurf].
<div style="clear:both"></div>


'''Solution structure of the ubiquitin domain of BCL-2 binding athanogene-1'''
==See Also==
 
*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
 
== References ==
==About this Structure==
<references/>
1WXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXV OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: Niraula, T N.]]
[[Category: Niraula TN]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Apoptosis]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:17:03 2008''

Latest revision as of 13:53, 9 May 2024

Solution structure of the ubiquitin domain of BCL-2 binding athanogene-1

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