9xo2: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9xo2 is ~~ON HOLD~~

==PEDV HNXX spike trimer with one D0 Down in complex with one N19 Fab==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9xo2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XO2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9XO2 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.71Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xo2 OCA], [https://pdbe.org/9xo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xo2 RCSB], [https://www.ebi.ac.uk/pdbsum/9xo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xo2 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/A0A7G4RNN0_PEDV A0A7G4RNN0_PEDV] S1 region attaches the virion to the cell membrane by interacting with the host receptor, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Porcine epidemic diarrhea virus]]

[[Category: Sus scrofa]]

[[Category: Li Z]]

[[Category: Liu J]]

[[Category: Su M]]

[[Category: Wang J]]

[[Category: Wang S]]

[[Category: Xiong X]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9xo2 is ON HOLD
+==PEDV HNXX spike trimer with one D0 Down in complex with one N19 Fab==
+<StructureSection load='9xo2' size='340' side='right'caption='[[9xo2]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9xo2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_epidemic_diarrhea_virus Porcine epidemic diarrhea virus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XO2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xo2 OCA], [https://pdbe.org/9xo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xo2 RCSB], [https://www.ebi.ac.uk/pdbsum/9xo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xo2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A7G4RNN0_PEDV A0A7G4RNN0_PEDV] S1 region attaches the virion to the cell membrane by interacting with the host receptor, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04200]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Porcine epidemic diarrhea virus]]
+[[Category: Sus scrofa]]
+[[Category: Li Z]]
+[[Category: Liu J]]
+[[Category: Su M]]
+[[Category: Wang J]]
+[[Category: Wang S]]
+[[Category: Xiong X]]