API5-FGF2 complex: Difference between revisions
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==Crystal Structure of API5-FGF2 Complex== | ==Crystal Structure of API5-FGF2 Complex== | ||
<StructureSection load='6L4O ' size='340' side='right' caption='Crystal structure of | <StructureSection load='6L4O ' size='340' side='right' caption='Crystal structure of apoptosis inhibitor 5 (grey) complex with fibroblast growth factor 2 (green) (PDB code [[6l4o]])' scene=''> | ||
BI3323-Aug2025 | BI3323-Aug2025 | ||
API5 and nuclear FGF2 form a complex that plays an important role in cancer-related gene regulation. Structural analysis of the API5-FGF2 complex reveals the key residues that mediate their interaction and connect major helical domains of API5. Beyond their structural association, the complex directly engages UAP56, a central factor shared by multiple mRNA export pathways. | '''Apoptosis inhibitor 5 (API5)''' and nuclear '''fibroblast growth factor 2 (FGF2)''' form a complex that plays an important role in cancer-related gene regulation. Structural analysis of the API5-FGF2 complex reveals the key residues that mediate their interaction and connect major helical domains of API5. Beyond their structural association, the complex directly engages UAP56, a central factor shared by multiple mRNA export pathways. | ||
{{Template:ClickGreenLinks}} | {{Template:ClickGreenLinks}} | ||
