9hef: Difference between revisions
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==Crystal Structure of MfpD from Mycobacterium tuberculosis== | |||
<StructureSection load='9hef' size='340' side='right'caption='[[9hef]], [[Resolution|resolution]] 1.83Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9hef]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HEF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hef OCA], [https://pdbe.org/9hef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hef RCSB], [https://www.ebi.ac.uk/pdbsum/9hef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hef ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SPI_MYCTU SPI_MYCTU] Effector protein that binds to the host serine protease cathepsin G on the macrophage cell membrane, inhibiting its enzymatic activity and the downstream activation of caspase-1-dependent apoptosis. Thus prevents macrophage pyroptosis and helps M.tuberculosis survival within host cells.<ref>PMID:22275911</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Haouz A]] | |||
[[Category: Micaletto M]] | |||
[[Category: Petrella S]] | |||
Latest revision as of 04:51, 27 May 2026
Crystal Structure of MfpD from Mycobacterium tuberculosis
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