9zf4: Difference between revisions
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New page: '''Unreleased structure''' The entry 9zf4 is ON HOLD Authors: Litchfield, C.M., Abiodun, W.O., Peterson, M.A., Moody, J.D. Description: The structure of human Vacuolar Protein Sorting ... |
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The | ==The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-II-83== | ||
<StructureSection load='9zf4' size='340' side='right'caption='[[9zf4]], [[Resolution|resolution]] 2.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZF4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C15:methyl+2-[(8R)-pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-benzothiazole-6-carboxylate'>A1C15</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zf4 OCA], [https://pdbe.org/9zf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zf4 RCSB], [https://www.ebi.ac.uk/pdbsum/9zf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zf4 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Abiodun WO]] | |||
[[Category: Litchfield CM]] | |||
[[Category: Moody JD]] | |||
[[Category: Peterson MA]] | |||
Latest revision as of 06:45, 22 April 2026
The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-II-83
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