1x45: Difference between revisions

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[[Image:1x45.gif|left|200px]]


<!--
==Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1==
The line below this paragraph, containing "STRUCTURE_1x45", creates the "Structure Box" on the page.
<StructureSection load='1x45' size='340' side='right'caption='[[1x45]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1x45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X45 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x45 OCA], [https://pdbe.org/1x45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x45 RCSB], [https://www.ebi.ac.uk/pdbsum/1x45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x45 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x45 TOPSAN]</span></td></tr>
{{STRUCTURE_1x45|  PDB=1x45  |  SCENE= }}
</table>
 
== Function ==
'''Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1'''
[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
1X45 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X45 OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x45_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x45 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Qin, X R.]]
[[Category: Qin XR]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Adapter protein xii alpha]]
[[Category: Amyloid beta a4 precursor protein-binding family some]]
[[Category: Member 1]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Neuron-specific xii protein]]
[[Category: Neuronal munc 18-1-interacting protein 1 mint-1]]
[[Category: Nppsfa]]
[[Category: Pdz domain]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:30:20 2008''

Latest revision as of 13:57, 9 May 2024

Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1

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