9zkc: Difference between revisions
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==Structure of RY12 domain of rabbit RyR1 in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; unbound and open RY12)== | |||
<StructureSection load='9zkc' size='340' side='right'caption='[[9zkc]], [[Resolution|resolution]] 2.66Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9zkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZKC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.66Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zkc OCA], [https://pdbe.org/9zkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zkc RCSB], [https://www.ebi.ac.uk/pdbsum/9zkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zkc ProSAT]</span></td></tr> | ||
[[Category: Clarke | </table> | ||
[[Category: Kim | == Function == | ||
[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Clarke OB]] | |||
[[Category: Kim K]] | |||
Latest revision as of 08:50, 16 September 2026
Structure of RY12 domain of rabbit RyR1 in the presence of ATP, ADP, and Mg2+ (mimicking physiological conditions; unbound and open RY12)
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