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==Crystal structure of the human galectin-1 in complex with p-Methoxyphenyl 3-O-benzyl-beta-D-galactopyranoside== | |||
<StructureSection load='28nm' size='340' side='right'caption='[[28nm]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[28nm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28NM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=28NM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=28nm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=28nm OCA], [https://pdbe.org/28nm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=28nm RCSB], [https://www.ebi.ac.uk/pdbsum/28nm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=28nm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Saviano M]] | |||
[[Category: Silvestri I]] | |||
Latest revision as of 08:21, 16 September 2026
Crystal structure of the human galectin-1 in complex with p-Methoxyphenyl 3-O-benzyl-beta-D-galactopyranoside
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