12iu: Difference between revisions

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'''Unreleased structure'''


The entry 12iu is ON HOLD  until Paper Publication
==CryoEM structure of monoclonal Fab 047-09M 2F03 binding the lateral patch of influenza virus H1 HA (A/California/04/2009)==
 
<StructureSection load='12iu' size='340' side='right'caption='[[12iu]], [[Resolution|resolution]] 3.06&Aring;' scene=''>
Authors: Swanson, O.M., Fernandez-Quintero, M.L., Han, J., Ward, A.B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[12iu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=12IU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=12IU FirstGlance]. <br>
Description: CryoEM structure of monoclonal Fab 047-09M 2F03 binding the lateral patch of influenza virus H1 HA (A/California/04/2009)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Swanson, O.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=12iu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=12iu OCA], [https://pdbe.org/12iu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=12iu RCSB], [https://www.ebi.ac.uk/pdbsum/12iu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=12iu ProSAT]</span></td></tr>
[[Category: Han, J]]
</table>
[[Category: Fernandez-Quintero, M.L]]
== Function ==
[[Category: Ward, A.B]]
[https://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fernandez-Quintero ML]]
[[Category: Han J]]
[[Category: Swanson OM]]
[[Category: Ward AB]]
Retrieved from "https://proteopedia.org/12iu"