1y12: Difference between revisions

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[[Image:1y12.gif|left|200px]]


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==Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa==
The line below this paragraph, containing "STRUCTURE_1y12", creates the "Structure Box" on the page.
<StructureSection load='1y12' size='340' side='right'caption='[[1y12]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1y12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y12 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_1y12| PDB=1y12  | SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y12 OCA], [https://pdbe.org/1y12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y12 RCSB], [https://www.ebi.ac.uk/pdbsum/1y12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y12 ProSAT], [https://www.topsan.org/Proteins/MCSG/1y12 TOPSAN]</span></td></tr>
 
</table>
'''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''
== Function ==
 
[https://www.uniprot.org/uniprot/HCP1_PSEAE HCP1_PSEAE] Required for assembly of the protein secretion apparatus HSI-I. Actively secreted during chronic infection of cystic fibrosis patients.
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y12_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y12 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.


==About this Structure==
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.,Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ Science. 2006 Jun 9;312(5779):1526-30. PMID:16763151<ref>PMID:16763151</ref>
1Y12 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y12 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus., Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ, Science. 2006 Jun 9;312(5779):1526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16763151 16763151]
</div>
[[Category: Pseudomonas aeruginosa]]
<div class="pdbe-citations 1y12" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Cuff, M E.]]
<references/>
[[Category: Joachimiak, A.]]
__TOC__
[[Category: MCSG, Midwest Center for Structural Genomics.]]
</StructureSection>
[[Category: Zhou, M.]]
[[Category: Large Structures]]
[[Category: Hemolysin-corregulation]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Mcsg]]
[[Category: Cuff ME]]
[[Category: Midwest center for structural genomic]]
[[Category: Joachimiak A]]
[[Category: Protein structure initiative]]
[[Category: Zhou M]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Psi]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:45:21 2008''
Retrieved from "https://proteopedia.org/1y12"