35ug: Difference between revisions
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==Human DVL2 PDZ domain in complex with Vangl2== | |||
<StructureSection load='35ug' size='340' side='right'caption='[[35ug]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[35ug]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=35UG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=35UG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=35ug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=35ug OCA], [https://pdbe.org/35ug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=35ug RCSB], [https://www.ebi.ac.uk/pdbsum/35ug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=35ug ProSAT]</span></td></tr> | ||
[[Category: Shen | </table> | ||
[[Category: Yang | == Disease == | ||
[https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Isolated anencephaly;Isolated exencephaly. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref> [https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).[UniProtKB:Q91ZD4] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Shen GB]] | |||
[[Category: Yang HM]] | |||
Latest revision as of 08:25, 16 September 2026
Human DVL2 PDZ domain in complex with Vangl2
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