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[[Image:1y4i.gif|left|200px]]
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{{STRUCTURE_1y4i|  PDB=1y4i  |  SCENE=  }}
'''Crystal structure of Citrobacter Freundii L-methionine-lyase'''


==Crystal structure of Citrobacter Freundii L-methionine-lyase==
<StructureSection load='1y4i' size='340' side='right'caption='[[1y4i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1y4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y4I FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y4i OCA], [https://pdbe.org/1y4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y4i RCSB], [https://www.ebi.ac.uk/pdbsum/1y4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y4i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q84AR1_CITFR Q84AR1_CITFR]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y4/1y4i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y4i ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes gamma-elimination of L-methionine. The crystal structure of MGL from Citrobacter freundii has been determined at 1.9 A resolution. The spatial fold of the protein is similar to those of MGLs from Pseudomonas putida and Trichomonas vaginalis. The comparison of these structures revealed that there are differences in PLP-binding residues and positioning of the surrounding flexible loops.


==Overview==
Structure of Citrobacter freundii L-methionine gamma-lyase.,Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:16511092<ref>PMID:16511092</ref>
L-Methionine gamma-lyase (MGL) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catalyzes gamma-elimination of L-methionine. The crystal structure of MGL from Citrobacter freundii has been determined at 1.9 A resolution. The spatial fold of the protein is similar to those of MGLs from Pseudomonas putida and Trichomonas vaginalis. The comparison of these structures revealed that there are differences in PLP-binding residues and positioning of the surrounding flexible loops.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1Y4I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4I OCA].
</div>
<div class="pdbe-citations 1y4i" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure of Citrobacter freundii L-methionine gamma-lyase., Mamaeva DV, Morozova EA, Nikulin AD, Revtovich SV, Nikonov SV, Garber MB, Demidkina TV, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt, 6):546-9. Epub 2005 Jun 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511092 16511092]
*[[Methionine gamma-lyase 3D structures|Methionine gamma-lyase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Citrobacter freundii]]
[[Category: Citrobacter freundii]]
[[Category: Methionine gamma-lyase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Demidkina TV]]
[[Category: Demidkina, T V.]]
[[Category: Garber MB]]
[[Category: Garber, M B.]]
[[Category: Mamaeva DV]]
[[Category: Mamaeva, D V.]]
[[Category: Morozova EA]]
[[Category: Morozova, E A.]]
[[Category: Nikonov SV]]
[[Category: Nikonov, S V.]]
[[Category: Nikulin AD]]
[[Category: Nikulin, A D.]]
[[Category: Revtovich SV]]
[[Category: Revtovich, S V.]]
[[Category: Plp-dependent enzyme]]
[[Category: Pyridoxal-5'-phosphate]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:52:03 2008''
Retrieved from "https://proteopedia.org/1y4i"