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'''Unreleased structure'''


The entry 32jy is ON HOLD
==Structure of the pathogenic variant G423S of Human SHMT2==
 
<StructureSection load='32jy' size='340' side='right'caption='[[32jy]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Giardina, G., Boumis, G., Di Matteo, A., Breccia, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[32jy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32JY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32JY FirstGlance]. <br>
Description: Structure of the pathogenic variant G423S of Human SHMT2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr>
[[Category: Breccia, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32jy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32jy OCA], [https://pdbe.org/32jy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32jy RCSB], [https://www.ebi.ac.uk/pdbsum/32jy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32jy ProSAT]</span></td></tr>
[[Category: Giardina, G]]
</table>
[[Category: Boumis, G]]
== Function ==
[[Category: Di Matteo, A]]
[https://www.uniprot.org/uniprot/GLYM_HUMAN GLYM_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.<ref>PMID:21876188</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boumis G]]
[[Category: Breccia S]]
[[Category: Di Matteo A]]
[[Category: Giardina G]]
Retrieved from "https://proteopedia.org/32jy"