45ic: Difference between revisions

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Created page with "'''Unreleased structure''' The entry 45ic is ON HOLD until Paper Publication Authors: Wang, X., Guo, F. Description: Complex structure of THZ-65 Fab bound to SARS-CoV-1 RBD Category: Unreleased Structures Category: Guo, F Category: Wang, X"
 
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'''Unreleased structure'''


The entry 45ic is ON HOLD  until Paper Publication
==Complex structure of THZ-65 Fab bound to SARS-CoV-1 RBD==
 
<StructureSection load='45ic' size='340' side='right'caption='[[45ic]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
Authors: Wang, X., Guo, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[45ic]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=45IC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=45IC FirstGlance]. <br>
Description: Complex structure of THZ-65 Fab bound to SARS-CoV-1 RBD
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=45ic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=45ic OCA], [https://pdbe.org/45ic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=45ic RCSB], [https://www.ebi.ac.uk/pdbsum/45ic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=45ic ProSAT]</span></td></tr>
[[Category: Guo, F]]
</table>
[[Category: Wang, X]]
== Function ==
[https://www.uniprot.org/uniprot/SPIKE_SARS SPIKE_SARS] May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.<ref>PMID:31199522</ref>  Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:14670965</ref> <ref>PMID:15496474</ref>  Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]  Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]<ref>PMID:19321428</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome-related coronavirus]]
[[Category: Guo F]]
[[Category: Wang X]]
Retrieved from "https://proteopedia.org/45ic"