1ysv: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1ysv.gif|left|200px]]


<!--
==Solution structure of the central region of the human GluR-B R/G pre-mRNA==
The line below this paragraph, containing "STRUCTURE_1ysv", creates the "Structure Box" on the page.
<StructureSection load='1ysv' size='340' side='right'caption='[[1ysv]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ysv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YSV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [https://pdbe.org/1ysv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB], [https://www.ebi.ac.uk/pdbsum/1ysv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ysv ProSAT]</span></td></tr>
{{STRUCTURE_1ysv|  PDB=1ysv  |  SCENE= }}
</table>
 
<div style="background-color:#fffaf0;">
'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
== Publication Abstract from PubMed ==
 
 
==Overview==
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.


==About this Structure==
A novel RNA pentaloop fold involved in targeting ADAR2.,Stefl R, Allain FH RNA. 2005 May;11(5):592-7. PMID:15840813<ref>PMID:15840813</ref>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813]
</div>
[[Category: Allain, F H.]]
<div class="pdbe-citations 1ysv" style="background-color:#fffaf0;"></div>
[[Category: Stefl, R.]]
== References ==
[[Category: Adar2]]
<references/>
[[Category: Nmr]]
__TOC__
[[Category: Pentaloop]]
</StructureSection>
[[Category: Rna]]
[[Category: Homo sapiens]]
[[Category: Rna editing]]
[[Category: Large Structures]]
[[Category: Stem-loop]]
[[Category: Allain FH]]
[[Category: Structure]]
[[Category: Stefl R]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:44:38 2008''
Retrieved from "https://proteopedia.org/1ysv"