1yv1: Difference between revisions

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[[Image:1yv1.gif|left|200px]]


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==Fully reduced state of nigerythrin (all ferrous)==
The line below this paragraph, containing "STRUCTURE_1yv1", creates the "Structure Box" on the page.
<StructureSection load='1yv1' size='340' side='right'caption='[[1yv1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1yv1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YV1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
{{STRUCTURE_1yv1|  PDB=1yv1  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yv1 OCA], [https://pdbe.org/1yv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yv1 ProSAT]</span></td></tr>
 
</table>
'''Fully reduced state of nigerythrin (all ferrous)'''
== Function ==
 
[https://www.uniprot.org/uniprot/NIGY_DESVH NIGY_DESVH] Exhibits NADH peroxidase activity (in vitro).
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
High-resolution crystal structures of Desulfovibrio vulgaris nigerythrin (DvNgr), a member of the rubrerythrin (Rbr) family, demonstrate an approximately 2-A movement of one iron (Fe1) of the diiron site from a carboxylate to a histidine ligand upon conversion of the mixed-valent ([Fe2(II),Fe1(III)]) to diferrous states, even at cryogenic temperatures. This Glu&lt;--&gt;His ligand "toggling" of one iron, which also occurs in DvRbr, thus, appears to be a characteristic feature of Rbr-type diiron sites. Unique features of DvNgr revealed by these structures include redox-induced flipping of a peptide carbonyl that reversibly forms a hydrogen bond to the histidine ligand to Fe1 of the diiron site, an intra-subunit proximal orientation of the rubredoxin-(Rub)-like and diiron domains, and an electron transfer pathway consisting of six covalent and two hydrogen bonds connecting the Rub-like iron with Fe2 of the diiron site. This pathway can account for DvNgr's relatively rapid peroxidase turnover. The characteristic combination of iron sites together with the redox-dependent iron toggling between protein ligands can account for the selectivity of Rbrs for hydrogen peroxide over dioxygen.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yv1_consurf.spt"</scriptWhenChecked>
1YV1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV1 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins., Iyer RB, Silaghi-Dumitrescu R, Kurtz DM Jr, Lanzilotta WN, J Biol Inorg Chem. 2005 Jun;10(4):407-16. Epub 2005 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15895271 15895271]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yv1 ConSurf].
[[Category: Desulfovibrio vulgaris]]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Iyer, R B.]]
</StructureSection>
[[Category: Kurtz, D M.]]
[[Category: Desulfovibrio vulgaris str. Hildenborough]]
[[Category: Lanzilotta, W N.]]
[[Category: Large Structures]]
[[Category: Silaghi-Dumitrescu, R.]]
[[Category: Iyer RB]]
[[Category: Diiron center]]
[[Category: Kurtz DM]]
[[Category: Electron transfer]]
[[Category: Lanzilotta WN]]
[[Category: Hemerythrin]]
[[Category: Silaghi-Dumitrescu R]]
[[Category: Peroxidase]]
[[Category: Rubredoxin]]
[[Category: Rubrerythrin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:49:21 2008''

Latest revision as of 09:00, 14 February 2024

Fully reduced state of nigerythrin (all ferrous)

1yv1, resolution 1.50Å

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