1yz2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1yz2.gif|left|200px]]


<!--
==Solution structure of Am2766==
The line below this paragraph, containing "STRUCTURE_1yz2", creates the "Structure Box" on the page.
<StructureSection load='1yz2' size='340' side='right'caption='[[1yz2]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1yz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_amadis Conus amadis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZ2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
{{STRUCTURE_1yz2|  PDB=1yz2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz2 OCA], [https://pdbe.org/1yz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yz2 RCSB], [https://www.ebi.ac.uk/pdbsum/1yz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O166_CONAA O166_CONAA] Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.<ref>PMID:14550575</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional (3D) NMR solution structure (MeOH) of the highly hydrophobic delta-conotoxin delta-Am2766 from the molluscivorous snail Conus amadis has been determined. Fifteen converged structures were obtained on the basis of 262 distance constraints, 25 torsion-angle constraints, and ten constraints based on disulfide linkages and H-bonds. The root-mean-square deviations (rmsd) about the averaged coordinates of the backbone (N, C(alpha), C) and (all) heavy atoms were 0.62+/-0.20 and 1.12+/-0.23 A, respectively. The structures determined are of good stereochemical quality, as evidenced by the high percentage (100%) of backbone dihedral angles that occupy favorable and additionally allowed regions of the Ramachandran map. The structure of delta-Am2766 consists of a triple-stranded antiparallel beta-sheet, and of four turns. The three disulfides form the classical 'inhibitory cysteine knot' motif. So far, only one tertiary structure of a delta-conotoxin has been reported; thus, the tertiary structure of delta-Am2766 is the second such example. Another Conus peptide, Am2735 from C. amadis, has also been purified and sequenced. Am2735 shares 96% sequence identity with delta-Am2766. Unlike delta-Am2766, Am2735 does not inhibit the fast inactivation of Na+ currents in rat brain Na(v)1.2 Na+ channels at concentrations up to 200 nM.


'''Solution structure of Am2766'''
Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels.,Sarma SP, Kumar GS, Sudarslal S, Iengar P, Ramasamy P, Sikdar SK, Krishnan KS, Balaram P Chem Biodivers. 2005 Apr;2(4):535-56. doi: 10.1002/cbdv.200590035. PMID:17192003<ref>PMID:17192003</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
1YZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_amadis Conus amadis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ2 OCA].
<div class="pdbe-citations 1yz2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Conus amadis]]
[[Category: Conus amadis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Balaram, P.]]
[[Category: Balaram P]]
[[Category: Iengar, P.]]
[[Category: Iengar P]]
[[Category: Krishnan, K S.]]
[[Category: Krishnan KS]]
[[Category: Kumar, G S.]]
[[Category: Kumar GS]]
[[Category: Sarma, S P.]]
[[Category: Sarma SP]]
[[Category: Sikdar, S K.]]
[[Category: Sikdar SK]]
[[Category: Sudarslal, S.]]
[[Category: Sudarslal S]]
[[Category: 15 structure]]
[[Category: Delta conotoxin]]
[[Category: Inhibitory cysteine knot motif]]
[[Category: Molluscivorous snail]]
[[Category: Nmr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:59:08 2008''

Latest revision as of 00:43, 21 November 2024

Solution structure of Am2766

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1yz2&oldid=4269523"