2coe: Difference between revisions

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New page: left|200px<br /> <applet load="2coe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2coe" /> '''Solution structure of BRCT domain of termin...
 
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[[Image:2coe.gif|left|200px]]<br />
<applet load="2coe" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2coe" />
'''Solution structure of BRCT domain of terminal deoxynucleotidyltransferase'''<br />


==About this Structure==
==Solution structure of BRCT domain of terminal deoxynucleotidyltransferase==
2COE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2COE OCA].  
<StructureSection load='2coe' size='340' side='right'caption='[[2coe]]' scene=''>
[[Category: DNA nucleotidylexotransferase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2coe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coe OCA], [https://pdbe.org/2coe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coe RCSB], [https://www.ebi.ac.uk/pdbsum/2coe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coe ProSAT], [https://www.topsan.org/Proteins/RSGI/2coe TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TDT_HUMAN TDT_HUMAN] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2coe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2coe ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Nagashima T]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: brct domain]]
[[Category: dna polymerase]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: teminal deoxynucleotidyltransferase]]
 
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