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[[Image:1z77.gif|left|200px]]
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{{STRUCTURE_1z77|  PDB=1z77  |  SCENE=  }}
'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''


==Crystal structure of transcriptional regulator protein from Thermotoga maritima.==
<StructureSection load='1z77' size='340' side='right'caption='[[1z77]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1z77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z77 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z77 OCA], [https://pdbe.org/1z77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z77 RCSB], [https://www.ebi.ac.uk/pdbsum/1z77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z77 ProSAT], [https://www.topsan.org/Proteins/MCSG/1z77 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9X0C0_THEMA Q9X0C0_THEMA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z77_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z77 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.


==Overview==
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.,Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774<ref>PMID:17588774</ref>
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1Z77 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA].
</div>
<div class="pdbe-citations 1z77" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17588774 17588774]
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
[[Category: Single protein]]
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Chruszcz, M.]]
[[Category: Chruszcz M]]
[[Category: Cymborowski, M.]]
[[Category: Cymborowski M]]
[[Category: Koclega, K D.]]
[[Category: Koclega KD]]
[[Category: Kudritska, M.]]
[[Category: Kudritska M]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Minor W]]
[[Category: Minor, W.]]
[[Category: Zimmerman MD]]
[[Category: Zimmerman, M D.]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tetr family]]
[[Category: Transcriptional regulator]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:15:52 2008''
Retrieved from "https://proteopedia.org/1z77"