2cry: Difference between revisions

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New page: left|200px<br /> <applet load="2cry" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cry" /> '''Solution structure of the fifth ig-like dom...
 
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[[Image:2cry.gif|left|200px]]<br />
<applet load="2cry" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cry" />
'''Solution structure of the fifth ig-like domain of human kin of IRRE like 3'''<br />


==About this Structure==
==Solution structure of the fifth ig-like domain of human kin of IRRE like 3==
2CRY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CRY OCA].  
<StructureSection load='2cry' size='340' side='right'caption='[[2cry]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cry OCA], [https://pdbe.org/2cry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cry RCSB], [https://www.ebi.ac.uk/pdbsum/2cry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cry ProSAT], [https://www.topsan.org/Proteins/RSGI/2cry TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN] Note=A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).  Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) [MIM:[https://omim.org/entry/612581 612581]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:19012874</ref>
== Function ==
[https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN] Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cry_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cry ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Kurosaki, C.]]
[[Category: Kurosaki C]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: ig fold]]
[[Category: kin of irregular chiasm-like protein 3]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nephrin-like 2]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:21:43 2007''
Retrieved from "https://proteopedia.org/2cry"