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[[Image:1zc5.gif|left|200px]]


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==Structure of the RNA signal essential for translational frameshifting in HIV-1==
The line below this paragraph, containing "STRUCTURE_1zc5", creates the "Structure Box" on the page.
<StructureSection load='1zc5' size='340' side='right'caption='[[1zc5]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1zc5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZC5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc5 OCA], [https://pdbe.org/1zc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zc5 ProSAT]</span></td></tr>
{{STRUCTURE_1zc5|  PDB=1zc5  |  SCENE= }}
</table>
 
<div style="background-color:#fffaf0;">
'''Structure of the RNA signal essential for translational frameshifting in HIV-1'''
== Publication Abstract from PubMed ==
 
 
==Overview==
Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.
Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.


==About this Structure==
Structure of the RNA signal essential for translational frameshifting in HIV-1.,Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:15907937<ref>PMID:15907937</ref>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the RNA signal essential for translational frameshifting in HIV-1., Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D, J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15907937 15907937]
</div>
[[Category: Fourmy, D.]]
<div class="pdbe-citations 1zc5" style="background-color:#fffaf0;"></div>
[[Category: Gaudin, C.]]
== References ==
[[Category: Guittet, E.]]
<references/>
[[Category: Mazauric, M H.]]
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[[Category: Traikia, M.]]
</StructureSection>
[[Category: Yoshizawa, S.]]
[[Category: Large Structures]]
[[Category: Rna bulged helix]]
[[Category: Fourmy D]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:27:02 2008''
[[Category: Gaudin C]]
[[Category: Guittet E]]
[[Category: Mazauric MH]]
[[Category: Traikia M]]
[[Category: Yoshizawa S]]
Retrieved from "https://proteopedia.org/1zc5"