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New page: left|200px<br /> <applet load="2dai" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dai" /> '''Solution Structure of the First UBA Domain ...
 
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[[Image:2dai.gif|left|200px]]<br />
<applet load="2dai" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dai" />
'''Solution Structure of the First UBA Domain in the Human Ubiquitin Associated Domain Containing 1 (UBADC1)'''<br />


==About this Structure==
==Solution Structure of the First UBA Domain in the Human Ubiquitin Associated Domain Containing 1 (UBADC1)==
2DAI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DAI OCA].  
<StructureSection load='2dai' size='340' side='right'caption='[[2dai]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dai OCA], [https://pdbe.org/2dai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dai RCSB], [https://www.ebi.ac.uk/pdbsum/2dai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dai ProSAT], [https://www.topsan.org/Proteins/RSGI/2dai TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBAC1_HUMAN UBAC1_HUMAN] Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<ref>PMID:15531880</ref> <ref>PMID:15746103</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/2dai_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dai ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Zhao C]]
[[Category: Zhao, C.]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: uba domain]]
[[Category: ubadc1]]
[[Category: ubiquitin associated domain containing 1]]
 
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Retrieved from "https://proteopedia.org/2dai"