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[[Image:241d.gif|left|200px]]


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==EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)==
The line below this paragraph, containing "STRUCTURE_241d", creates the "Structure Box" on the page.
<StructureSection load='241d' size='340' side='right'caption='[[241d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[241d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=241D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=241d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=241d OCA], [https://pdbe.org/241d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=241d RCSB], [https://www.ebi.ac.uk/pdbsum/241d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=241d ProSAT]</span></td></tr>
{{STRUCTURE_241d|  PDB=241d  |  SCENE= }}
</table>
 
__TOC__
'''EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)'''
</StructureSection>
 
[[Category: Large Structures]]
 
[[Category: Berger I]]
==Overview==
[[Category: Fredian A]]
The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a four stranded molecule in which two parallel duplexes intercalate with opposite polarity, using cytosine.protonated cytosine base pairs. The intercalation motif in this structure is extended by adenine.adenine base pairs. Two topologically distinct broad grooves are found in the lath-like central part of the molecule with the phosphate groups on one side bent over towards each other, stabilized by bridging water molecules. At the 3' ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.
[[Category: Kang C]]
 
[[Category: Moyzis R]]
==About this Structure==
[[Category: Ratliff R]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=241D OCA].  
[[Category: Rich A]]
 
==Reference==
Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT)., Berger I, Kang C, Fredian A, Ratliff R, Moyzis R, Rich A, Nat Struct Biol. 1995 May;2(5):416-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664099 7664099]
[[Category: Berger, I.]]
[[Category: Fredian, A.]]
[[Category: Kang, C.]]
[[Category: Moyzis, R.]]
[[Category: Ratliff, R.]]
[[Category: Rich, A.]]
[[Category: Arallel-stranded tetraplex]]
[[Category: Base intercalated]]
[[Category: Mismatched]]
[[Category: Quadruple helix]]
[[Category: U-dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:22:08 2008''
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