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New page: left|200px<br /> <applet load="2dim" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dim" /> '''Solution structure of the Myb_DNA-binding d...
 
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[[Image:2dim.gif|left|200px]]<br />
<applet load="2dim" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2dim" />
'''Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein'''<br />


==About this Structure==
==Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein==
2DIM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DIM OCA].  
<StructureSection load='2dim' size='340' side='right'caption='[[2dim]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dim OCA], [https://pdbe.org/2dim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dim RCSB], [https://www.ebi.ac.uk/pdbsum/2dim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dim ProSAT], [https://www.topsan.org/Proteins/RSGI/2dim TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CDC5L_HUMAN CDC5L_HUMAN] Note=A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.
== Function ==
[https://www.uniprot.org/uniprot/CDC5L_HUMAN CDC5L_HUMAN] DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.<ref>PMID:9038199</ref> <ref>PMID:9632794</ref> <ref>PMID:9468527</ref> <ref>PMID:10570151</ref> <ref>PMID:11101529</ref> <ref>PMID:11082045</ref> <ref>PMID:11544257</ref> <ref>PMID:12927788</ref> <ref>PMID:18583928</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2dim_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dim ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoneyama M]]
[[Category: Yoneyama, M.]]
[[Category: cell cycle]]
[[Category: dna binding]]
[[Category: myb_dna-binding domain]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: spliceosome]]
[[Category: structural genomics]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:33:21 2007''
Retrieved from "https://proteopedia.org/2dim"